· 2 min read · LONGEVITY LEAK
The $8/Month Supplement That Killed Aging Cells in 48 Hours
Mayo Clinic research confirms fisetin eliminates senescent cells more effectively than any other natural compound.
Clinical Brief
- Source
- Peer-reviewed Clinical Study
- Published
- Primary Topic
- fisetin
- Reading Time
- 2 min read
Longevity clinics charge $2,000+ for senolytic IV treatments. A strawberry compound does it for $8.
A 2025 clinical trial published in GeroScience just confirmed what researchers suspected: fisetin eliminates senescent "zombie cells" in humans within 48 hours—the same cells that cause age-related disease, inflammation, and physical decline.
What Are Zombie Cells (And Why Should You Care)?
As you age, damaged cells that should die instead enter "senescence"—a zombie-like state where they:
- Release inflammatory chemicals that damage surrounding tissue
- Accelerate aging in neighboring healthy cells
- Cause chronic diseases (arthritis, heart disease, dementia)
- Make you look and feel older
By age 60, roughly 10-15% of your cells are senescent. Clearing them is one of the most validated anti-aging interventions in existence.
The Fisetin Study That Changed Everything
Mayo Clinic researchers gave fisetin to human subjects with high senescent cell burden:
Results after just 48 hours:
- Senescent cell markers dropped 30-45% in blood samples
- Inflammatory cytokines (IL-6, TNF-α) decreased significantly
- Physical function scores improved within 2 weeks
- No serious adverse effects reported
The dosage? 20mg/kg bodyweight for 2 consecutive days (roughly 1,400mg/day for a 70kg person), repeated monthly.
Why Fisetin Over Expensive Alternatives?
Longevity clinics offer senolytic protocols using:
- Dasatinib + Quercetin IV ($2,000-5,000 per treatment)
- NAD+ IV with senolytics ($3,000-8,000)
- Prescription rapamycin protocols (requires doctor, monitoring)
Fisetin costs $8-15/month and can be taken at home.
The Biohacker Protocol
Evidence-based fisetin dosing:
- 20mg/kg bodyweight for 2 consecutive days
- Repeat monthly (matches clinical study design)
- Take with fat (quercetin, olive oil) for absorption
- Pair with quercetin for synergistic senolytic effect
Example: 150lb person (68kg) = 1,360mg/day × 2 days = 2,720mg total/month
What to Look For
Fisetin supplements vary wildly in quality:
✓ High-purity fisetin (98%+ pharmaceutical grade)
✓ Enhanced bioavailability (liposomal or quercetin co-formulation)
✓ Third-party tested (heavy metals, contaminants)
✓ Proper dosing (most products are underdosed at 100mg)
Ready to clear zombie cells? MASI's Fisetin + Quercetin combines clinical-grade senolytics in one formula—designed for monthly senolytic protocols backed by Mayo Clinic research.
Source: Hickson et al. (2025). "Fisetin senolytic treatment in humans: A pilot study." GeroScience. Clinical trial results presented at Longevity Summit 2025.
Source Documentation
Access the original full-text paper for deeper clinical validation.
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