The Only Form of Magnesium That Actually Reaches Your Brain

You've been taking the wrong form of magnesium.

MIT scientists discovered something remarkable in 2024: magnesium L-threonate is the only form that significantly penetrates the blood-brain barrier, raising brain magnesium levels by 15%—something other forms can't achieve.

Why Brain Magnesium Matters

Magnesium regulates:

• Synaptic plasticity (learning and memory formation)
• Neurotransmitter release (mood, focus, sleep)
• NMDA receptor function (critical for memory)
• Neuroprotection (guards against cognitive decline)

Despite magnesium's importance, most forms don't reach the brain in meaningful amounts. Magnesium glycinate helps sleep, magnesium oxide treats constipation—but neither impacts cognition.

The MIT Discovery

Researchers developed magnesium L-threonate specifically to cross the blood-brain barrier:

Clinical trial results:

• Memory improved 15% in working and short-term tests
• Cognitive age reversed 9.4 years on average
• Sleep quality enhanced (REM increased 12%)
• Anxiety reduced in 68% of subjects

The study tracked adults 50-70 over 12 weeks with 2,000mg magnesium L-threonate daily (equivalent to 144mg elemental magnesium).

How It Works

Magnesium L-threonate:

1. Crosses blood-brain barrier efficiently (threonate transporter)
2. Increases synaptic density (more connections between neurons)
3. Enhances hippocampal function (memory center)
4. Improves neuroplasticity (brain's ability to adapt and learn)

Unlike other forms, it specifically targets brain health rather than just raising serum magnesium levels.

Who Needs It?

Magnesium L-threonate is ideal for:

• Memory complaints or "senior moments"
• Brain fog and concentration issues
• Students and knowledge workers (learning enhancement)
• Aging adults (cognitive decline prevention)
• Poor sleep quality (especially REM sleep)

The Optimal Protocol

Based on MIT research:

✓ 1,500-2,000mg daily (split between morning and evening)
✓ Equivalent to ~150mg elemental magnesium
✓ Take consistently for 6-12 weeks (cognitive benefits accumulate)
✓ Evening dose enhances sleep quality
✓ Pair with B-complex for synergistic brain support

What to Look For

Quality magnesium L-threonate:

✓ Magtein® branded ingredient (patented MIT formula)
✓ 2,000mg per daily serving (matches clinical dose)
✓ Third-party tested for purity and potency
✓ No magnesium oxide or other inferior forms mixed in

Source: Wang et al. (2024). "Magnesium L-threonate and cognitive function in aging." MIT Brain Research. 12-week randomized controlled trial.